Immune Defense Peptide Blend Nasal Spray

TA-1 & LL37 Nasal Spray

Elaboration:

• LL-37Ta1:
• This hybrid peptide combines the properties of LL-37 and Tα1. LL-37 is a cathelicidin antimicrobial peptide, while Tα1 is known for its anti-endotoxin activity. 

• Anti-endotoxin Activity:
• LL-37Tα1 effectively neutralizes LPS, a component of bacterial cell walls that triggers inflammatory responses. It does this by directly binding to LPS and reducing its ability to induce toxicity in cells like macrophages. 

• LPS-Induced Cytotoxicity:
• LL-37Tα1 reduces the harmful effects of LPS on macrophages. LPS can cause inflammation and cell damage. The hybrid peptide helps to mitigate these effects, as shown in the study by reducing levels of nitric oxide and pro-inflammatory cytokines like TNF-α, IL-6, and IL-1β. 

• LL-37:
• This peptide, alone, has various roles in the immune system. It can directly kill bacteria by disrupting their cell membranes and also modulates the immune response by influencing cell migration, proliferation, and differentiation. 

• LL-37's Limitations:
• While LL-37 shows great promise, it faces challenges such as high production costs, susceptibility to degradation, and potential toxicity at high concentrations. 

• LL-37's Potential:
• Despite the limitations, LL-37's ability to target both bacteria and the host's immune response makes it a potential candidate for developing new therapeutic strategies, especially for biofilm-mediated infections. 

 

Nasal Spray Bottle Dosing 

Each spray is 80mcgs of TA-1 & LL37

BUD:

• 3 months refrigerated
• 1 year frozen at -20c